Whole Genome Bisulfite Sequencing (WGBS) uses bisulfite treatment of genomic DNA, converting unmethylated cytosine (C) to uracil (U), while methylated cytosines remain unchanged. Combining this with high-throughput sequencing technology allows precise identification of DNA methylation dynamics across the entire genome at single-base resolution.

NuSeq Bio utilizes WGBS technology to accurately locate methylation sites, effectively detecting over 75% of genomic loci, reducing background noise, and ensuring reliable data. Its single-base resolution characteristic comprehensively maps fine methylation patterns, precisely screens differentially methylated regions (DMRs), providing key insights for developmental mechanisms, disease variations, breeding of animals and plants, and environmental responses, aiding in revealing the mysteries of methylation regulation.

NuSeq Bio has a mature WGBS full-process system, from library construction, deep sequencing to multi-dimensional analysis, ensuring high-quality data delivery. Choose us to empower your scientific exploration with "gold standard" technology, decoding the spatiotemporal code of methylation regulation!

MeRIP-seq (RNA Methylation Immunoprecipitation Sequencing) is a core technology for analyzing RNA epigenetic modifications. It uses antibodies to specifically bind methylated bases, enriching methylated fragments through RNA immunoprecipitation, combined with high-throughput sequencing to precisely locate methylation sites across the entire transcriptome, revealing dynamic modification patterns.

NuSeq Bio's MeRIP-seq offers high sensitivity and depth of correlation analysis, developing low-input MeRIP-seq library preparation technology, lowering sample input thresholds. With mature experimental systems and multi-dimensional analysis capabilities, we provide efficient and reliable research solutions, deciphering methylation modifications and gene expression regulatory networks. Input samples also provide transcriptome quantification information, maximizing data value.

NuSeq Bio provides one-stop services from experimental design, library preparation, sequencing to bioinformatics mining. Relying on stable platforms and professional teams ensures short turnaround times, steady data quality, and deep data interpretation. Use technology as a blade to decode the dynamic map of RNA methylation, empowering your scientific breakthroughs!

ChIP-Seq (Chromatin Immunoprecipitation Sequencing) is a core technology for studying protein-DNA interactions. By using specific antibodies to immunoprecipitate target proteins, it enriches their bound genomic DNA fragments. Combined with high-throughput sequencing, it identifies regulatory sites such as histone modifications and transcription factor binding across the entire genome, revealing dynamic associations between gene expression and epigenetics. Widely applied in tumor mechanisms, developmental regulation, plant stress resistance, and more.

NuSeq Bio offers ultra-low input, efficient delivery, cost-effective, multi-omics integrated, and highly accurate technical solutions. Relying on stable platforms and professional teams ensures precise and reliable data, empowering you to decode gene regulatory codes and explore gene regulatory networks and disease mechanisms.

ATAC-Seq (Assay for Transposase-Accessible Chromatin with high-throughput sequencing) efficiently inserts sequencing adapters into open chromatin regions using Tn5 transposase, enriching these regions' DNA. Combined with high-throughput sequencing, it detects chromatin openness across the entire genome, exploring transcription factor binding sites, nucleosome positioning, and active regulatory element distributions. Comprehensive mapping of active regulatory elements across the genome. Applications span developmental differentiation mechanisms, tumor microenvironment dynamics, disease target discovery, crop stress resistance regulation, providing multidimensional chromatin accessibility data support for life sciences, medicine, and agricultural research.

NuSeq Bio's ATAC-Seq features "rapid, low-input, precise" advantages, short experimental cycles, standardized processes ensuring high reproducibility, and cost-effective coverage of genome-wide open regions, aiding in resolving transcription factor binding, nucleosome positioning, and epigenetic regulatory networks.