NAR | A Side Story of Ribosomal Pausing: How Boron Responsiveness in Plants is Regulated by NIP5;1
In eukaryotes, gene expression involves multiple cellular compartments. After DNA is transcribed in the nucleus, pre-mRNA undergoes capping, splicing, 3′ end cleavage, and poly(A) addition to form mature mRNA, which is then exported from the nucleus and translated in the cytoplasm. mRNA stability is regulated by the 5′ or 3′ UTR. For example, uORFs in the 5′ UTR can induce mRNA degradation through ribosomal pausing, while reducing the translation efficiency of the main ORF.
2025/03/26
